The Hippo Pathway, Neural Stem Cells and Brain Growth
Grant number: 1103604 | Funding period: 2016 - 2018
Completed
Abstract
During organism development, the brain grows to the right size without overgrowing. Neural stem cells are key regulators of brain size. We will define how the Hippo pathway crosstalks with nutrition-induced signals to control proliferation of neural stem cells and brain size. As well as producing important insights into normal growth, we will increase our understanding of brain diseases associated with aberrant brain growth, such as cancer.